Qiagen

QIAcube Connect MDx

The QIAcube Connect MDx is designed to perform automated isolation and purification of nucleic acids in molecular diagnostic and/or molecular biology applications. The system is intended for use by professional users, such as technicians and physicians trained in molecular biological techniques and the operation of the QIAcube Connect MDx system.

description

QIAcube Connect MDx is used for fully automated nucleic acid extraction with QIAGEN’s spin-column kits in molecular diagnostic and clinical research applications.

QIAcube is expanding the benefits of automated sample processing to IVD protocols with advanced digital capabilities, connectivity and full IVD compliance. The device allows research and diagnostic labs to fully automate and track their trusted QIAGEN spin-column extraction and purification protocols – at the push of a button. The dual software environments provide users with application versatility and increased confidence in valuable insights.

As the next generation QIAcube for IVD nucleic acid extraction, this device offers a flexible system with over 150 standard protocols, including several IVD protocols. Users can access the largest and most dynamic range of protocols related to different IVD and research applications, which can be seamlessly integrated with downstream assays.

Performance

The QIAcube Connect MDx expands the benefits of automated sample prep to all molecular routine diagnostic and clinical research laboratories. The plug-and-play instrument simplifies and streamlines your purification procedures by fully automating the trusted QIAGEN spin-column kits. No change of chemistry is required, assuring fast startup and immediate results in IVD and molecular biology applications. With advanced digital capabilities and full IVD compliance, the innovative QIAcube enables you to use proven QIAGEN spin-column kits, standardize your results and obtain valuable insights for diagnostic and research settings.

Principle

QIAcube Connect MDx enables continued use of trusted QIAGEN spin-column kits and eliminates the need for tedious manual steps. The innovative QIAcube Connect MDx controls integrated components including a centrifuge, heated shaker, pipetting system, UV LED and robotic gripper. This enables the QIAcube Connect MDx to fully automate more than 150 standard protocols, including several IVD protocols.

The QIAcube starter pack provides everything you need to use your kits on the instrument (i.e., rotor adapters, filter tips and reagent bottles).

Applications

QIAcube Connect MDx is highly suitable for routine diagnostic labs and clinical research laboratories performing column-based nucleic acid extraction using QIAGEN spin column technology in modular and moderate throughput workflows. QIAcube Connect MDx is also suitable for academic research laboratories as well as pharmaceutical, biotechnology, and biomedical research laboratories performing applications, such as:

Infectious disease (or assays for pathogen detection and viral load monitoring)
Sequencing/sequencing analysis
Genotyping
Gene expression analysis
Microbiome research
And many more…

Specifications

Features	Specifications
Altitude	Up to 2000 m (6500 ft)
Centrifuge	10,640 rpm maximum, 12,000 x g maximum, swing-out rotor maximum 45°, 12 rotor positions
Environmental class	3K20 (IEC 60721-3-3)
Instrument dimensions	Dimensions (hood closed): width 65 cm (25.6 in.), height 58 cm (22.8 in.), depth 62 cm (24.4 in.); Dimensions (hood open): width 65 cm (25.6 in.), height 86 cm (34 in.), depth 62 cm (24.4 in.); Mass: QIAcube Connect MDx: 71.5 kg (157.6 lb.), Accessories: 3 kg (6.6 lb.)
Operating temperature	20 to 25ºC (68 to 77ºF)
Pipetting system	Syringe size 1 ml, pipetting range 5–900 µl
Place of operation	For indoor use only
Pollution level	2
Relative humidity	20–75% (noncondensing)
Shaker	Speed 100–2000 rpm, amplitude 2 mm, heating range of ambient temperature to 70°C (158°F), ramp-up time of <5 minutes from ambient temperature to 55°C (±3°C). Difference in the temperature detected by the internal sensor and the temperature of the sample liquid is approximately –2°C.
Software	QIAGEN protocols are pre-installed on the QIAcube Connect MDx or can be downloaded in the Resources section below
Storage conditions	Temperature: 5ºC to 40ºC (41ºF to 104ºF) in enclosed location; Relative humidity: Max. 75% (non-condensing)
Table capacity	Up to 12 samples per run
Technical data	Power: 100–240 V AC, 50/60 Hz, 650 VA Mains supply voltage fluctuations are not to exceed 10% of nominal supply voltages. Note: The apparent power can exceed 650 VA for up to 2 seconds during the centrifuge acceleration and can reach an approximate value of 1000 VA.; Fuse: 2x T6.3A L 250V; Overvoltage category: II
Touchscreen	10.4” TFT Touchscreen, active area 211.2 x 158.4 mm, resolution 800*600 SVGA
UV lamp	Wavelength: 278nm; Optical power: 200-300mW

FEATURES & BENEFITS

Automates selected QIAGEN DSP and non-DSP kits and the PAXgene Blood RNA Kit
Offers two software environments for specific user needs: IVD mode (for validated IVD applications) or Research mode (for research applications)
Automated DNA, RNA and protein sample processing for a large range of clinical sample types
Generates standardized results perfectly suited for IVD requirements when used with QIAGEN DSP kits